The Mirror reports that Wenger wants respect shown to the striker because he was a good servant to Arsenal and also because he is with the Champions.
£24million was enough to tempt Arsenal to let him come to Old Trafford last summer and this has resulted in van Persie becoming a figure of hate with the Emirates regulars.
Wenger said: “We will respect the players that have played for us a long time as we always have done and treat them well before and after the game. As a champion or not as a champion it is exactly the same.
“What I want is for us to have a good game and to beat them, it doesn't matter what kind if status they come with. We'll see.”
United may well start the game at Arsenal on Sunday as Champions if they manage to beat Aston Villa on Monday night.