The Holland forward had only 13 touches of the ball against his former club, three of which were while taking corners, before Van Gaal replaced him with 18-year-old James Wilson for the last 15 minutes.
Indeed, in the whole of 2014, Van Persie has scored only eight goals in 21 Barclays Premier League games.
Van Gaal said that, when he was in charge of Bayern Munich, Germany striker Mario Gomez had had fewer touches during some matches, but accepted that Van Persie has been struggling for form.
He said: "I do think 13 is few for a striker
I want to improve that
You can count his touches on the ball but more important is how he is playing.
"It was a very bad game for him
That is why I changed him
When I change a player, it is not because he is the best player on the pitch
You are doing something wrong
I believe in the players
When I change them, normally, it is because they are doing something not good in their performance.
"When you pick up this match it is easy to put a question about 13 touches
Okay
But strikers do not touch the ball often
That is their profession.
"Now I have a surprise for you
I had an international striker, Mario Gomez
He touched the ball nine times during Bayern Munich matches in my time."
Asked what Van Persie needs to do to get back to the level of being the best striker in England, the United boss added: "It is a question of confidence, or maybe scoring a wonderful goal at the right moment.
"You know how strikers are
They have to score goals
They feel like that
It is not that I am asking that
I have said they have to be an attacking point and help our team in the third and fourth phase
For me, it is not important who scores
The team has to score."
Van Gaal also warned Van Persie that he will have to fight for his place as he prepares to welcome Radamel Falcao back to his squad after injury.
Falcao's loan spell at Old Trafford has been disrupted by injuries, but Van Gaal is hopeful he will be in the squad for today's visit of Hull.
Asked if Falcao's return would increase the pressure on Van Persie, Van Gaal said: "Every player in my selection has to fight for his position and I shall always take the best of the players and it must also be suitable for the mix of players
So it is also an obligation of a player that he does that."
It is not just Falcao poised to provide a huge boost for United, but Argentina defender Marcos Rojo is also in contention to face the Tigers after being out with a shoulder injury.
Phil Jones (shin), Jonny Evans (ankle) and Rafael (hamstring) are all still out injured, though.
Source : PA
Source: PA