The United pair have been selected in manager Fabio Capello's 23-man squad for the match in Seville on Wednesday, 11th February.
Full England squad:
Goalkeepers: Robert Green (West Ham), Joe Hart (Man City), David James (Portsmouth).
Defenders: Wayne Bridge (Man City), Ashley Cole (Chelsea), Rio Ferdinand (Man Utd), Phil Jagielka (Everton), Glen Johnson (Portsmouth), John Terry (Chelsea), Matthew Upson (West Ham), Luke Young (Aston Villa).
Midfielders: David Beckham (LA Galaxy), Gareth Barry (Aston Villa), Michael Carrick (Man Utd), Stewart Downing (Middlesbrough), Frank Lampard (Chelsea), James Milner (Aston Villa), Shaun Wright-Phillips (Man City), Ashley Young (Aston Villa).
Forwards: Gabriel Agbonlahor (Aston Villa), Carlton Cole (West Ham), Peter Crouch (Portsmouth), Emile Heskey (Aston Villa).