Over 70 of the 81 passengers and crew on board Chapecoense's charter flight to Medellin, Colombia, died in a late-night crash, with 22 journalists also among the travelling party.
Chapacoense were on their way to play in the first leg of the Copa Sudamericana final against Atletico Nacional, which had been due to take place on Wednesday evening.
The club have only been a part of Brazil's top flight for the past three seasons, and were aiming for the greatest achievement in their 43-year history.
Manchester United have rebuilt after deadly air disasters, which shocked the football world in 1958.
United, the 20-times English champions, said in a statement on Twitter: "The thoughts of everyone at Manchester United are with @ChapecoenseReal & all those affected by the tragedy in Colombia."
Red Devils captain Wayne Rooney added: "Sad news to wake up to today
Thoughts are with @ChapecoenseReal and their family and friends."
Source: PA