The United trio all missed Tuesday night's Champions League tie through injury but are expected to have recovered in time for Sunday's match at Stamford Bridge.
Rio Ferdinand, however, is unlikely to have shaken off his calf injury in time for the top-of-the-table clash.
"Hopefully Vidic, Giggs and Berbatov will be ready for Sunday but I don't know if Rio will make it," manager sIR Alex Ferguson told MUTV