Here, we assess three key areas where the game could be won and lost.
ZLATAN IBRAHIMOVIC v JOHN STONES Two players at opposite ends of their careers who have both started the season in impressive form
Ibrahimovic has had no trouble finding the net early in his United career and has experience on big derby days in Spain, Italy, France and Holland
He will look to dominate the same territory Stones has to protect, and the aerial battle should be particularly important
Stones has licence to bring the ball forward under Guardiola but may have other priorities on this occasion
PAUL POGBA v DAVID SILVA
Whether or not the pair are in close proximity at all times, they will lead the respective battles for control of the midfield
Pogba will cover more ground, using his long, easy strides to power forward and back, while Silva's modus operandi involves finding pockets of space and playing between the lines
If either man manages to dictate their own terms, the result could follow close behind
RAHEEM STERLING v LUKE SHAW
The England pair spent most of the international break training together at St George's Park, so there should be no secrets
Sterling has been reinvigorated by Guardiola's arrival at City and, when confident, is a tricky, rapid threat on the right flank
Shaw is expected to be fit despite not travelling to Slovakia and can expect the most thorough examination of his fitness since returning from a year out
Source : PA
Source: PA