Ferdinand is currently out of action because of a calf injury and because he is not expected to make the international fixture, the captain’s job could be passed back to John Terry as Steven Gerrard is also out.
Ferguson said: "Rio has been doing a bit of running. He will be ready for the game after the internationals. I wouldn't have thought he would have a chance before that."
He added: "I don't think it would be wise for him to be called up by England. He hasn't played for us since January."