The veteran Manchester United full-back has not played since the New Year's Day victory over West Brom at the Hawthorns, when he was fortunate not to be dismissed for a professional foul on Graham Dorrans.
It was his 602nd appearance for the Red Devils. He also won 85 England caps.
Neville played in United's FA Youth Cup-winning side in 1992 alongside David Beckham, Nicky Butt, Ryan Giggs, Keith Gillespie, Robbie Savage and Paul Scholes and made first-team debut in the UEFA Cup against Torpedo Moscow later that same year.
He becomes the second member of United's famed `Class of 92' to call it a day following Butt's retirement from the game last season.
Neville's career has been blighted by injury over the last few years and it was obvious to anyone who was at the West Brom game, or the visit to Stoke in October when the full-back was equally fortunate to escape a red card, that his time at the top level was almost over.
Source: PA
Source: PA