City boss Guardiola currently enjoys an eight-point advantage over his United counterpart and events at Old Trafford this weekend could have a significant say in where the trophy ends up.
Here, Press Association Sport looks at the two managers' respective careers to date, with Mourinho's numbers on the left.
7 Clubs managed 3
4 Countries managed in 3
8 League titles 6
8 Domestic cups 4
2 Champions League 2
2 Europa League 0
264 Premier League matches 53
64.39 Premier League win percentage 69.81
Source : PA
Source: PA