The pair are the most highly-rated players to emerge from last season's United Youth Cup squad, and Ferguson has already confirmed his intention to let them join feeder club Royal Antwerp on loan for the entire duration of the current campaign.
But the Red Devils chief does not believe playing in the Belgian Second Division will have any impact on their ability to win full caps despite the fact they are still only 18.
'Those two Irish boys are outstanding,' Ferguson said. 'I would not be surprised if Johnny Evans and Darron Gibson made the full Northern Ireland squad this season.
'I know that Northern Ireland are not endowed with anything like the standard of 20 years ago.
'Nonetheless, these two lads - while lacking experience - have great quality. It would not be a shock to me at all if they played for Northern Ireland.'
Gibson and Evans will be joined by full-back Danny Simpson in Antwerp, with Dong Fangzhou also returning to Belgium in the hope he can gain a UK work permit once he has completed three years at the club in December.