The duo missed the easy passage that United made past Stoke City at Old Trafford last night, so neither was really missed but the game against Chelsea is a whole different ball game.
As well as Rooney and Nani being fit, Ferguson is also hopeful that he will also have the services of Ashley Young, but that is touch and go, this may be a game too soon for him.
"We're hopeful Wayne Rooney, Nani and possibly Ashley Young will be fit for Sunday," Ferguson told MUTV.