Aston Villa, meanwhile, are seeking a win against the Gunners or could be cut further adrift at the bottom
Here, Press Association Sport looks at five talking points ahead of the weekend's top-flight fixtures
BATTLE OF PHILOSOPHIES?
Manchester United will bid to respond from their Champions League exit at Bournemouth, a side whose attractive philosophy was rewarded with a victory at Chelsea last weekend
Louis van Gaal's United have been criticised by a number of their illustrious former players for their tactics, but a win on the south coast could go some way to proving their title credentials.
MAGPIES RISING
Steve McClaren's Newcastle are 18th entering this weekend's fixtures, but a win over Jurgen Klopp's Liverpool must have done wonders for morale and belief
The Magpies face a different test this Sunday, against a Tottenham side determined to deliver on their potential and in buoyant mood following their mauling of Monaco.
MIGHTY FALL
Should Leicester beat Chelsea on Monday night the Foxes will retain top spot in the standings and will surely be considered realistic contenders for the title Jose Mourinho's men picked up in May
Chelsea could drop into the bottom three before kick-off - depending on results elsewhere - and the likelihood of the self-proclaimed Special One being out of a job would increase with a ninth loss in 16 games despite their European success in midweek.
FOXES IN BOXES
Jamie Vardy is experiencing a goal drought - he did not score in last week's win as Leicester team-mate Riyad Mahrez's hat-trick earned a 3-0 win over Swansea
It ended a record run of scoring in 11 straight Premier League games for Vardy, who has been linked with a move to opponents Chelsea
His pace will worry Chelsea and he could soon be back on the goal trail.
RUDDERLESS SWANS?
Swansea go to Manchester City after sacking manager Garry Monk
It is a thankless task for caretaker boss Alan Curtis and will provide little of a gauge for the future as City can tear apart the best teams, let alone one in disarray and reeling from the departure of their boss.
Source : PA
Source: PA