The pair were both absent from the side that lost at Stamford Bridge on Monday, but while the pair are back, there are still doubts about defenders Jonny Evans and Nemanja Vidic, who also sat out the Stamford Bridge replay.
United will be looking for the victory that would put them 18 points clear of City and virtually assure the title goes back to Old Trafford after it's twelve month loan.
"Wayne and Rafa have started training this morning," United manager Ferguson said to the club's official website. "Which is good news.
"Hopefully, they will be fine by Monday. Jonny Evans and Nemanja Vidic are not there yet but, hopefully, they will start training maybe Friday or Saturday morning. We have a little bit of time on our hands to get most of the troops ready for the game.
"It's a derby game with a difference from a few years ago. We have to get used to playing Manchester City in big games and that's the case again.
"The important thing is to win Monday's game. It'll be a big game for City. They'll want to come and derail us for a spell. We're at home and our consistency is there for all to see. I expect us to perform really well on Monday."