Evans looked the most likely replacement for fellow centre-back Nemanja Vidic for the game against Jose Mourinho's side at The San Siro on Tuesday night - the Serbian defender is suspended for the tie having been handed a one match ban for his sending off in the Club World Cup Final in December.
''It is a recurrence of the ankle injury I had before and is a bit tender,'' Evans has said.
''I caught it when I kicked the ground during the game.
''At this point, I don't know whether I will be fit for the San Siro.
"The doctor has said that he will have a look at it so we will have a better picture then.''