The United pair both picked up knock's in the 2-1 home win against Bolton on Saturday and manager Sir Alex Feguson has admitted they are injury doubts ahead of the trip to Russia on Wednesday.
"Giggs is doubtful for Moscow with a knock," said Ferguson.
"Evra we will look at tomorrow (Sunday) and he may be doubtful. Vidic should be okay and definitely will be fit for Liverpool (a week on Sunday).
"I think (Dimitar) Berbatov will be okay and we will try and get Wayne Rooney ready but he will be okay for Liverpool."