The United midfielder has a thigh injury and will miss the final Group E game at Old Trafford on Wednesday night although manager Sir Alex Ferguson has admitted that he should be fit for the match against Tottenham at the weekend.
Christiano Ronaldo is also a major doubt with a hip injury.
"Cristiano is doubtful and Michael is out," Fergie has said.
"Those are the only injury problems we have.
"Michael should be ready for Saturday, but we'll have to see how Cristiano is."