The moody one picked up a knee injury in the game against Blackburn Rovers at the end of last month and has been out of the side for the games with CSKA Moscow and the trip to Chelsea before the international break.
Maybe the 28 year old could change United’s luck by returning after the draw in the Champion’s League and the Premier League slip up at Stamford Bridge.
"I received a kick in my knee during the Blackburn match and I needed some rest and some treatment, but I'm okay now and I'll play in Malta," Berbatov said.
Providing Berbatov comes through the midweek fixture unscathed, he should take up an attacking roll in the home game against Everton at the weekend.